Why NAD+ infusions at IV-MEDICAL.COM?

The IV-medical.com NAD plus IV infusion

At IV-medical.com we offer the NAD plus IV infusion as part of a thoughtful and medically grounded approach to supporting cellular energy metabolism and overall patient well being. NAD plus is a critical cofactor in human physiology that participates directly in glycolysis and the Krebs cycle by accepting electrons and forming NADH which then feeds into oxidative phosphorylation to ultimately drive the conversion of ADP to ATP. In theory increasing the availability of NAD plus may support these pathways and improve the efficiency of cellular energy production particularly in states where NAD plus levels may be relatively depleted such as aging metabolic stress or illness. Although the measurable biochemical benefit in otherwise healthy individuals is likely modest due to tight physiologic regulation and the fact that NAD plus is not usually the primary limiting factor in ATP generation we acknowledge that there is a growing body of anecdotal clinical experience suggesting that patients frequently report increased energy improved mental clarity and an overall sense of well being following NAD plus IV infusions. These subjective benefits while not yet strongly supported by large scale internal medicine randomized trials are meaningful to patients and are one of the reasons this therapy continues to be offered in carefully selected settings. At IV-medical.com we believe it is appropriate to provide therapies that may offer benefit when done responsibly and transparently while clearly communicating the limits of current evidence.

At the same time we emphasize that safety and proper medical practice are paramount. Any IV infusion including NAD plus requires appropriate clinical assessment prior to administration. This includes evaluation of the patient’s volume status comorbid conditions and most importantly basic laboratory values. Serum sodium must be checked prior to administration of IV fluids because administering intravenous fluids without knowing the sodium level can lead to serious complications including worsening hyponatremia or hypernatremia which can result in neurologic injury. Giving IV fluids without checking sodium is a deviation from standard medical practice and may constitute malpractice unless the patient is in an emergent hypotensive state where immediate fluid resuscitation is required. Therefore at IV-medical.com we strongly advocate that patients undergoing NAD plus IV infusion have appropriate laboratory evaluation including electrolytes prior to treatment unless there is a clear emergency indication. This ensures that we are not only offering a therapy that may provide symptomatic benefit but also adhering to the highest standards of internal medicine and patient safety.

In summary the IV-medical.com NAD plus IV infusion is based on a biologically plausible mechanism involving cellular energy metabolism and while its objective benefits may be modest in many individuals there is consistent anecdotal evidence of improved energy and well being in patients who receive it. We believe it is a reasonable therapy to offer within a medically supervised framework that prioritizes appropriate screening laboratory evaluation and adherence to safe infusion practices.

Selected Internal Medicine and Related Literature on NAD plus Biology and Metabolism

NAD Intermediates The Biology and Therapeutic Potential of NMN and NR

Yoshino J Baur J A Imai S I

Cell Metabolism

2018